Peter learns from a psychic through a palm reading that he had a fascinating past life as Griffin Peterson, a dignified gentleman who fought for the love of Lady Redbush from 17th century England, ruled by the fierce King Stewart, to the newly founded American colony of Quahog.

Peter retells three of Stephen King’s greatest works: Stand by Me, starring Peter, Quagmire, Cleveland, and Joe as twelve-year-olds; Misery, starring Brian and Stewie, and The Shawshank Redemption, starring Peter and Cleveland.

After drowning his sorrows when he learns his ex-girlfriend Jillian is getting married, Brian discovers that he has hooked up with The Hills star Lauren Conrad. Brian wants out of the relationship until he realizes that Conrad may be the perfect match for him, if only he is willing to let Jillian go.

Stewie starts going to the gym with Peter after he gets beaten up by Joe’s baby daughter Susie, but just when it seems that his hard work is paying off, Peter reveals that he’s been giving him an anabolic steroid. Meanwhile, Chris begins dating Connie D’Amico at school, only to see her popularity subside.

After Brian is arrested for drug possession, he launches a campaign to legalize marijuana. Mayor West passes the law, and the whole town goes to pot. However, Carter Pewterschmidt starts losing money as a result, so he does whatever it takes to get pot banned once again.

Meg becomes a born-again Christian and tries to convert Brian from atheism. Meanwhile, Stewie is furious he doesn’t get to ask the cast of Star Trek: The Next Generation any questions at a convention, so he kidnaps the cast and forces them to hang out with him.

Peter cashes in a raffle ticket from 1989 and wins a golf outing with O. J. Simpson. When he befriends Simpson and brings him home to meet the family, the residents of Quahog aren’t so welcoming of the infamous running back and try to force him out of town.

Peter participates in some medical experiments to pay off his debt, including one that sees him getting injected with the “gay gene”. Peter winds up in a gay relationship and leaves Lois and the rest of the family heartbroken, though they realize the most important thing is that Peter is happy.

Bonnie finally gives birth to her baby, a beautiful girl named Susie, with whom Stewie falls in love and will do anything to win her heart. Meanwhile, Joe borrows $20,000 from a loan shark to pay for Bonnie’s medical bills, and plans to steal the money from Mr. Pewterschmidt to pay off his debt.

Peter does everything he can to get a promotion at work, but he must first be sent back to repeat the third grade in order to qualify. Meanwhile, Frank Sinatra, Jr. returns to Quahog to buy the local nightclub with Brian and make it the hottest new spot in town, but Stewie has a few ideas of his own.